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Its drawback may look like its very punishing and can allow the opponent to surprise you via a mid-combat spell, but I never really saw that scenario play out since its damage prevention ability is a a conditional static ability so as long as its on when damage is dealt, it wont be prevented. (Thank you, @fenaris!) It usually plays out somewhat like a colorless Ashenmoor Gouger / Chimeric Idol where you typically dont bother trying to block with it (why am I blocking with my aggro guys anyway?) and, if need be, you cast a spell pre-combat to activate it (typically I used a large coin, like a quarter, to denote whether it was on or off)

SR Super Rare Ultimate Slayer X SPELL Your opponent cannot activate monster effects in response to this card's activation

Yes, toxic does stack

As we said, the Ancient and Future mechanic looks like its really going to change the game and we have some superb support cards that synergise well with decks built around each mechanic